There is a lot of research going on about the biomedical usage of fullerene molecules on mstnano.com. since its discovery there is a lot of study going on about fullerenes. These substances are insoluble in aqueous medium and so it is difficult to check its properties and do research on it. But this issue can be overcome using techniques such as encapsulated fullerenes with molecules that are hydrophilic, suspending fullerene molecules in other solvents and conjugating other molecules with fullerene.
- Antioxidising property: fullerenes are antioxidants and this is because of the numerous conjugated double bonds that are present in them. They have a high affinity towards electrons because their energy is low in their molecular orbital. They can react with several radicals till they are consumed. One molecule of C60 can interact with around 34 methyl radicals before they are used up. They are also known as the most efficient radical sponges or radical scavengers of the world. These antioxidants can be localized within their cells and hence they are highly preferred.
- Antiviral property: Fullerenes have a high level of antiviral properties. The most exciting part of this is the ability of the fullerenes to suppress the multiplication of the HIV virus and this it delays the onset of AIDS syndrome. Derivative 2 and dendrofullerene trans isomer can inhibit the protease of HIV and thereby prevent replication of HIV1. There are bivalent metal derivatives present in the amino acid derivatives of these compounds like C60-1-Ala. They can be an active agent used to prevent HIV and also replication of human cytomegalovirus. The molecules of these compounds are inserted in the hydrophobic protein domains. The amino acid derivative of fullerene also targets the reverse transcriptase of HIV too. These molecules tend to be a lot more active as compared to non nucleoside inhibitors that are analog and are widely used. Antiproliferative and antibacterial properties are found in the cationic fullerene derivatives. Most of the fullerene derivatives are known to inhibit the proliferation of hepatitis C virus.
- Gene and drug delivery: Drug delivery is properly transported by the pharmaceutical compound to its site of actions. The gene delivery is the introduction of foreign DNA into cells to bring the desired effect. It is therefore very important to deliver these molecules with great efficacy and safely. Fullerenes are the class of inorganic carriers where the molecules are preferred as the good bio compability, retaining the biological activity, greater selectivity and are also small enough too diffused. DNA sequence are attach to the acid derivatives of amino of fullerenes. These sequences are then detached from the carrier with the denaturation of amino groups and loss.